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KMID : 1039420160500010010
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Journal of Pathology and Translational Medicine
2016 Volume.50 No. 1 p.10 ~ p.16
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Menetrier’s Disease: Its Mimickers and Pathogenesis
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Huh Won-Jae
Robert J. Coffey
Mary Kay Washington
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Abstract
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Menetrier’s disease is a rare protein-losing hypertrophic gastropathy. Histologically, it can be mistaken for other disorders showing hypertrophic gastropathy. The pathogenesis of Menetrier’s disease is not fully understood; however, it appears that the epidermal growth factor receptor (EGFR) ligand, transforming growth factor alpha, contributes to the pathogenesis of this disorder. In this review, we will discuss disease entities that can mimic Menetrier’s disease and the role of EGFR signaling in Menetrier’s disease.
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KEYWORD
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Menetrier’s disease, Gastric polyp, Transforming growth factor alpha
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